Evolution, Safety, and Highly Pathogenic Influenza Viruses
نویسندگان
چکیده
منابع مشابه
Evolution, safety, and highly pathogenic influenza viruses.
Experience with influenza has shown that predictions of virus phenotype or fitness from nucleotide sequence are imperfect and that predicting the timing and course of evolution is extremely difficult. Such uncertainty means that the risk of experiments with mammalian-transmissible, possibly highly virulent influenza viruses remains high even if some aspects of their laboratory biology are reass...
متن کاملMallards and Highly Pathogenic Avian Influenza Ancestral Viruses, Northern Europe
Outbreaks of highly pathogenic avian influenza (HPAI), which originate in poultry upon transmission of low pathogenic viruses from wild birds, have occurred relatively frequently in the last decade. During our ongoing surveillance studies in wild birds, we isolated several influenza A viruses of hemagglutinin subtype H5 and H7 that contain various neuraminidase subtypes. For each of the recorde...
متن کاملA42 Evolution and spatial dissemination of the highly pathogenic Asian H5 avian influenza viruses
A40 Persistent circulation of highly divergent HIV-1M lineages in the Congo Basin Region M. Tongo, J.R. Dorfman, Tulio de Oliveira, D.P. Martin, Africa Centre for Population Health, University of KwaZulu-Natal, South Africa, Division of Computational Biology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, Institute of Medical Research and Stud...
متن کاملEvolution of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam between 2001 and 2007
Highly pathogenic avian influenza (HPAI) H5N1 viruses have caused dramatic economic losses to the poultry industry of Vietnam and continue to pose a serious threat to public health. As of June 2008, Vietnam had reported nearly one third of worldwide laboratory confirmed human H5N1 infections. To better understand the emergence, spread and evolution of H5N1 in Vietnam we studied over 300 H5N1 av...
متن کاملEvolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variants.
Highly pathogenic avian H5N1 viruses have circulated in South-east Asia for more than a decade and have now spread to more than 60 countries. The evolution of these viruses is characterized by frequent reassortment of the so-called 'internal' genes, creating novel genotypes. Additionally, over time, the surface glycoprotein, haemagglutinin (HA), which is the primary target of the adaptive immun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1223204